| Gender |
|
|
| Male |
56.1% |
83/148 |
| Female |
43.9% |
65/148 |
| General |
|
|
| Birth Length abnormalities |
11.5% |
18/157 |
| < P3 : Birth length less than 3rd percentile |
10.2% |
16/157 |
| > P98 : Birth length greater than 97th percentile |
1.3% |
2/157 |
| Birth Weight abnormalities |
17.3% |
28/162 |
| > P98 : Large for gestational age |
0.6% |
1/162 |
| < P3 : Small for gestational age |
16.7% |
27/162 |
| Birth Head circumference abnormalities |
8.9% |
14/157 |
| < P3 : Congenital microcephaly |
7.6% |
12/157 |
| > P98 : Macrocephaly at birth |
1.3% |
2/157 |
| Current Height abnormalities |
42.5% |
71/167 |
| < P3 : Short stature |
40.7% |
68/167 |
| > P98 : Tall stature |
1.8% |
3/167 |
| Current Weight abnormalities |
20.6% |
33/160 |
| > P98 : Increased body weight |
6.3% |
10/160 |
| < P3 : Decreased body weight |
14.4% |
23/160 |
| Current Head circumference abnormalities |
14.2% |
23/162 |
| < P3 : Microcephaly |
12.3% |
20/162 |
| > P98 : Macrocephaly |
1.9% |
3/162 |
| Neurology |
|
|
| Neurological abnormalities |
51.1% |
69/135 |
| Seizures |
14.1% |
19/135 |
| Global developmental delay |
10.4% |
14/135 |
| Generalized hypotonia |
8.9% |
12/135 |
| Generalized tonic-clonic seizures |
8.1% |
11/135 |
| Poor coordination |
8.1% |
11/135 |
| Absence seizures |
6.7% |
9/135 |
| Mild global developmental delay |
4.4% |
6/135 |
| Delayed speech and language development |
3.7% |
5/135 |
| Focal seizures |
3.7% |
5/135 |
| Febrile seizures |
3.0% |
4/135 |
| Generalized seizures |
3.0% |
4/135 |
| Migraine |
3.0% |
4/135 |
| Motor delay |
3.0% |
4/135 |
| Pain insensitivity |
3.0% |
4/135 |
| Delayed gross motor development |
2.2% |
3/135 |
| Gait imbalance |
2.2% |
3/135 |
| Generalized myoclonic seizures |
2.2% |
3/135 |
| Memory impairment |
2.2% |
3/135 |
| Migraine with aura |
2.2% |
3/135 |
| Poor fine motor coordination |
2.2% |
3/135 |
| Ataxia |
1.5% |
2/135 |
| Atonic seizures |
1.5% |
2/135 |
| Cerebral palsy |
1.5% |
2/135 |
| Delayed fine motor development |
1.5% |
2/135 |
| Dysarthria |
1.5% |
2/135 |
| Dyslexia |
1.5% |
2/135 |
| Expressive language delay |
1.5% |
2/135 |
| Gait disturbance |
1.5% |
2/135 |
| Generalized tonic seizures |
1.5% |
2/135 |
| Generalized neonatal hypotonia |
1.5% |
2/135 |
| Hand tremor |
1.5% |
2/135 |
| Impaired pain sensation |
1.5% |
2/135 |
| Intellectual disability |
1.5% |
2/135 |
| Intellectual disability, mild |
1.5% |
2/135 |
| Muscular hypotonia |
1.5% |
2/135 |
| Syncope |
1.5% |
2/135 |
| Unilateral strabismus |
1.5% |
2/135 |
| Vertigo |
1.5% |
2/135 |
| Abnormal muscle tone |
0.7% |
1/135 |
| Abnormality of fontanelles |
0.7% |
1/135 |
| Abnormality of pain sensation |
0.7% |
1/135 |
| Abnormality of the temporomandibular joint |
0.7% |
1/135 |
| Abnormality of the vestibular nerve |
0.7% |
1/135 |
| Absent speech |
0.7% |
1/135 |
| Anterior pituitary hypoplasia |
0.7% |
1/135 |
| Anxiety |
0.7% |
1/135 |
| Attention deficit hyperactivity disorder |
0.7% |
1/135 |
| Brain atrophy |
0.7% |
1/135 |
| Broad-based gait |
0.7% |
1/135 |
| Central apnea |
0.7% |
1/135 |
| Central hypotonia |
0.7% |
1/135 |
| Delayed social development |
0.7% |
1/135 |
| Delayed closure of the anterior fontanelle |
0.7% |
1/135 |
| Dementia |
0.7% |
1/135 |
| Dyscalculia |
0.7% |
1/135 |
| Dysgraphia |
0.7% |
1/135 |
| Dysphagia |
0.7% |
1/135 |
| EEG abnormality |
0.7% |
1/135 |
| EEG with generalized polymorphic epileptiform discharges |
0.7% |
1/135 |
| EEG with generalized epileptiform discharges |
0.7% |
1/135 |
| Facial hypotonia |
0.7% |
1/135 |
| Focal seizures with impairment of consciousness or awareness |
0.7% |
1/135 |
| Focal tonic seizures |
0.7% |
1/135 |
| Focal myoclonic seizures |
0.7% |
1/135 |
| Frequent falls |
0.7% |
1/135 |
| Gait ataxia |
0.7% |
1/135 |
| Gelastic seizures |
0.7% |
1/135 |
| Generalized clonic seizures |
0.7% |
1/135 |
| Headache |
0.7% |
1/135 |
| High pitched voice |
0.7% |
1/135 |
| Hyperextensibility of the knee |
0.7% |
1/135 |
| Impaired tactile sensation |
0.7% |
1/135 |
| Impaired distal tactile sensation |
0.7% |
1/135 |
| Increased intracranial pressure |
0.7% |
1/135 |
| Infantile muscular hypotonia |
0.7% |
1/135 |
| Joint hypermobility |
0.7% |
1/135 |
| Kinetic tremor |
0.7% |
1/135 |
| Limb dystonia |
0.7% |
1/135 |
| Moderate global developmental delay |
0.7% |
1/135 |
| Muscular hypotonia of the trunk |
0.7% |
1/135 |
| Myoclonus |
0.7% |
1/135 |
| Myokymia |
0.7% |
1/135 |
| Neonatal hypotonia |
0.7% |
1/135 |
| Paresthesia |
0.7% |
1/135 |
| Polymorphic focal epileptiform discharges |
0.7% |
1/135 |
| Poor suck |
0.7% |
1/135 |
| Poor eye contact |
0.7% |
1/135 |
| Poor motor coordination |
0.7% |
1/135 |
| Short attention span |
0.7% |
1/135 |
| Shuffling gait |
0.7% |
1/135 |
| Shyness |
0.7% |
1/135 |
| Sleep disturbance |
0.7% |
1/135 |
| Sleep myoclonus |
0.7% |
1/135 |
| Slowed slurred speech |
0.7% |
1/135 |
| Spastic diplegia |
0.7% |
1/135 |
| Specific learning disability |
0.7% |
1/135 |
| Speech articulation difficulties |
0.7% |
1/135 |
| Synovitis |
0.7% |
1/135 |
| Tachypnea |
0.7% |
1/135 |
| Tethered cord |
0.7% |
1/135 |
| Truncal ataxia |
0.7% |
1/135 |
| Behavioral problems |
86.5% |
109/126 |
| Attention deficit hyperactivity disorder |
34.9% |
44/126 |
| Autism |
32.5% |
41/126 |
| Anxiety |
15.1% |
19/126 |
| Short attention span |
13.5% |
17/126 |
| Delayed speech and language development |
9.5% |
12/126 |
| Obsessive-compulsive behavior |
9.5% |
12/126 |
| Aggressive behavior |
8.7% |
11/126 |
| Impaired social interactions |
8.7% |
11/126 |
| Impulsivity |
7.9% |
10/126 |
| Autistic behavior |
5.6% |
7/126 |
| Oppositional defiant disorder |
4.8% |
6/126 |
| Abnormal aggressive, impulsive or violent behavior |
4.0% |
5/126 |
| Behavioral abnormality |
4.0% |
5/126 |
| Hyperactivity |
4.0% |
5/126 |
| Repetitive compulsive behavior |
4.0% |
5/126 |
| Global developmental delay |
3.2% |
4/126 |
| Mild global developmental delay |
3.2% |
4/126 |
| Poor eye contact |
3.2% |
4/126 |
| Recurrent hand flapping |
3.2% |
4/126 |
| Abnormal emotion/affect behavior |
2.4% |
3/126 |
| Autism with high cognitive abilities |
2.4% |
3/126 |
| Developmental regression |
2.4% |
3/126 |
| Expressive language delay |
2.4% |
3/126 |
| Inappropriate sexual behavior |
2.4% |
3/126 |
| Self-injurious behavior |
2.4% |
3/126 |
| Sensory impairment |
2.4% |
3/126 |
| Specific learning disability |
2.4% |
3/126 |
| Absent speech |
1.6% |
2/126 |
| Delayed gross motor development |
1.6% |
2/126 |
| Depression |
1.6% |
2/126 |
| Inflexible adherence to routines or rituals |
1.6% |
2/126 |
| Intellectual disability, mild |
1.6% |
2/126 |
| Irritability |
1.6% |
2/126 |
| Receptive language delay |
1.6% |
2/126 |
| Restlessness |
1.6% |
2/126 |
| Stereotypic behavior |
1.6% |
2/126 |
| Tics |
1.6% |
2/126 |
| Violent behavior |
1.6% |
2/126 |
| Abnormal social behavior |
0.8% |
1/126 |
| Abnormal eating behavior |
0.8% |
1/126 |
| Abnormal fear/anxiety-related behavior |
0.8% |
1/126 |
| Apathy |
0.8% |
1/126 |
| Cognitive impairment |
0.8% |
1/126 |
| Decreased facial expression |
0.8% |
1/126 |
| Delayed fine motor development |
0.8% |
1/126 |
| Dyslexia |
0.8% |
1/126 |
| Emotional lability |
0.8% |
1/126 |
| Enuresis nocturna |
0.8% |
1/126 |
| Inappropriate behavior |
0.8% |
1/126 |
| Insomnia |
0.8% |
1/126 |
| Intellectual disability, moderate |
0.8% |
1/126 |
| Low frustration tolerance |
0.8% |
1/126 |
| Moderate global developmental delay |
0.8% |
1/126 |
| Motor delay |
0.8% |
1/126 |
| No social interaction |
0.8% |
1/126 |
| Pain insensitivity |
0.8% |
1/126 |
| Pica |
0.8% |
1/126 |
| Poor gross motor coordination |
0.8% |
1/126 |
| Precocious puberty |
0.8% |
1/126 |
| Psychosis |
0.8% |
1/126 |
| Self-biting |
0.8% |
1/126 |
| Sensory neuropathy |
0.8% |
1/126 |
| Severe expressive language delay |
0.8% |
1/126 |
| Shyness |
0.8% |
1/126 |
| Sleep disturbance |
0.8% |
1/126 |
| Slurred speech |
0.8% |
1/126 |
| Tongue thrusting |
0.8% |
1/126 |
| Brain abnormality |
26.9% |
25/93 |
| EEG abnormality |
5.4% |
5/93 |
| Brain atrophy |
3.2% |
3/93 |
| Arachnoid cyst |
2.2% |
2/93 |
| Heterotopia |
2.2% |
2/93 |
| Abnormality of the sella turcica |
1.1% |
1/93 |
| Abnormal length of corpus callosum |
1.1% |
1/93 |
| Abnormality of brain morphology |
1.1% |
1/93 |
| Abnormality of the spinal cord |
1.1% |
1/93 |
| Aplasia/Hypoplasia of the corpus callosum |
1.1% |
1/93 |
| Aplasia/Hypoplasia of the cerebellar vermis |
1.1% |
1/93 |
| Ataxia |
1.1% |
1/93 |
| Cerebellar hypoplasia |
1.1% |
1/93 |
| Choroid plexus cyst |
1.1% |
1/93 |
| Colpocephaly |
1.1% |
1/93 |
| Deformed sella turcica |
1.1% |
1/93 |
| Delayed CNS myelination |
1.1% |
1/93 |
| Delayed closure of the anterior fontanelle |
1.1% |
1/93 |
| Dysplastic corpus callosum |
1.1% |
1/93 |
| Hydrocephalus |
1.1% |
1/93 |
| Macrocephaly |
1.1% |
1/93 |
| Meningitis |
1.1% |
1/93 |
| Microcephaly |
1.1% |
1/93 |
| Optic nerve hypoplasia |
1.1% |
1/93 |
| Perivascular spaces |
1.1% |
1/93 |
| Pineal cyst |
1.1% |
1/93 |
| Posterior fossa cyst |
1.1% |
1/93 |
| Retrocerebellar cyst |
1.1% |
1/93 |
| Small pituitary gland |
1.1% |
1/93 |
| Subdural hemorrhage |
1.1% |
1/93 |
| Ventriculomegaly |
1.1% |
1/93 |
| Facial abnormalities |
|
|
| Abnormality of the ear |
52.9% |
72/136 |
| Protruding ear |
23.5% |
32/136 |
| Macrotia |
22.1% |
30/136 |
| Low-set ears |
10.3% |
14/136 |
| Large fleshy ears |
3.7% |
5/136 |
| Large earlobe |
2.9% |
4/136 |
| Anteverted ears |
2.2% |
3/136 |
| Low-set, posteriorly rotated ears |
2.2% |
3/136 |
| Preauricular skin tag |
2.2% |
3/136 |
| Uplifted earlobe |
2.2% |
3/136 |
| Abnormality of earlobe |
1.5% |
2/136 |
| Abnormality of the pinna |
1.5% |
2/136 |
| Attached earlobe |
1.5% |
2/136 |
| Bilateral conductive hearing impairment |
1.5% |
2/136 |
| Chronic otitis media |
1.5% |
2/136 |
| Periauricular skin pits |
1.5% |
2/136 |
| Posteriorly rotated ears |
1.5% |
2/136 |
| Preauricular pit |
1.5% |
2/136 |
| Abnormality of the helix |
0.7% |
1/136 |
| Abnormality of the antihelix |
0.7% |
1/136 |
| Abnormality of the Eustachian tube |
0.7% |
1/136 |
| Abnormality of the tympanic membrane |
0.7% |
1/136 |
| Aplasia/Hypoplasia of the external ear |
0.7% |
1/136 |
| Asymmetry of the ears |
0.7% |
1/136 |
| Blocked Eustachian tube |
0.7% |
1/136 |
| Cholesteatoma |
0.7% |
1/136 |
| Conductive hearing impairment |
0.7% |
1/136 |
| Cupped ear |
0.7% |
1/136 |
| Hypoplastic helices |
0.7% |
1/136 |
| Long eyelashes |
0.7% |
1/136 |
| Prominent eyelashes |
0.7% |
1/136 |
| Prominent antihelix |
0.7% |
1/136 |
| Prominent ear helix |
0.7% |
1/136 |
| Recurrent otitis media |
0.7% |
1/136 |
| Recurrent infections |
0.7% |
1/136 |
| Skin dimples |
0.7% |
1/136 |
| Thickened helices |
0.7% |
1/136 |
| Abnormality of the eye |
60.3% |
82/136 |
| Hypertelorism |
17.6% |
24/136 |
| Long eyelashes |
16.9% |
23/136 |
| Synophrys |
14.0% |
19/136 |
| Thick eyebrow |
13.2% |
18/136 |
| Strabismus |
5.9% |
8/136 |
| Upslanted palpebral fissure |
5.1% |
7/136 |
| Amblyopia |
3.7% |
5/136 |
| Anteverted nares |
3.7% |
5/136 |
| Downslanted palpebral fissures |
3.7% |
5/136 |
| Large eyes |
2.9% |
4/136 |
| Long eyebrows |
2.9% |
4/136 |
| Prominent eyelashes |
2.9% |
4/136 |
| Highly arched eyebrow |
2.2% |
3/136 |
| Myopia |
2.2% |
3/136 |
| Abnormality of vision |
1.5% |
2/136 |
| Abnormal eye morphology |
1.5% |
2/136 |
| Astigmatism |
1.5% |
2/136 |
| Epicanthus |
1.5% |
2/136 |
| Horizontal eyebrow |
1.5% |
2/136 |
| Long palpebral fissure |
1.5% |
2/136 |
| Nystagmus |
1.5% |
2/136 |
| Prominent epicanthal folds |
1.5% |
2/136 |
| Short palpebral fissure |
1.5% |
2/136 |
| Unilateral strabismus |
1.5% |
2/136 |
| Abnormal shape of the palpebral fissure |
0.7% |
1/136 |
| Abnormality of the palpebral fissures |
0.7% |
1/136 |
| Abnormality of the cornea |
0.7% |
1/136 |
| Abnormality of the conjunctiva |
0.7% |
1/136 |
| Abnormality of the eyelashes |
0.7% |
1/136 |
| Abnormality of the eyelid |
0.7% |
1/136 |
| Almond-shaped palpebral fissure |
0.7% |
1/136 |
| Bilateral ptosis |
0.7% |
1/136 |
| Blepharitis |
0.7% |
1/136 |
| Congenital strabismus |
0.7% |
1/136 |
| Congenital nystagmus |
0.7% |
1/136 |
| Congenital bilateral ptosis |
0.7% |
1/136 |
| Deeply set eye |
0.7% |
1/136 |
| Difficulty adjusting from dark to light |
0.7% |
1/136 |
| Entropion |
0.7% |
1/136 |
| Esotropia |
0.7% |
1/136 |
| Exotropia |
0.7% |
1/136 |
| Hyperopic astigmatism |
0.7% |
1/136 |
| Hypotelorism |
0.7% |
1/136 |
| Iris coloboma |
0.7% |
1/136 |
| Lacrimal duct aplasia |
0.7% |
1/136 |
| Nasolacrimal duct obstruction |
0.7% |
1/136 |
| Proptosis |
0.7% |
1/136 |
| Ptosis |
0.7% |
1/136 |
| Sparse eyelashes |
0.7% |
1/136 |
| Telecanthus |
0.7% |
1/136 |
| Abnormality of the nose |
75.9% |
104/137 |
| Abnormality of the nose |
33.6% |
46/137 |
| Bulbous nose |
24.1% |
33/137 |
| Wide nasal bridge |
21.2% |
29/137 |
| Anteverted nares |
19.0% |
26/137 |
| Prominent nasal bridge |
14.6% |
20/137 |
| Wide nasal base |
10.9% |
15/137 |
| Prominent nasal tip |
10.2% |
14/137 |
| Broad nasal tip |
7.3% |
10/137 |
| Wide nose |
2.9% |
4/137 |
| Depressed nasal bridge |
2.2% |
3/137 |
| Abnormality of the nasal tip |
1.5% |
2/137 |
| Long philtrum |
1.5% |
2/137 |
| Short nose |
1.5% |
2/137 |
| Abnormal nasal base |
0.7% |
1/137 |
| Abnormal size of nasopharyngeal adenoids |
0.7% |
1/137 |
| Abnormality of the nasal bridge |
0.7% |
1/137 |
| Absent nasal bridge |
0.7% |
1/137 |
| Bulbous tips of toes |
0.7% |
1/137 |
| Choanal atresia |
0.7% |
1/137 |
| Chronic sinusitis |
0.7% |
1/137 |
| Deviated nasal septum |
0.7% |
1/137 |
| Hypertelorism |
0.7% |
1/137 |
| Hypoplastic frontal sinuses |
0.7% |
1/137 |
| Hypoplastic nasal bridge |
0.7% |
1/137 |
| Short columella |
0.7% |
1/137 |
| Thin anteverted nares |
0.7% |
1/137 |
| Abnormality of the mouth |
93.5% |
130/139 |
| Macrodontia |
41.7% |
58/139 |
| Thin upper lip vermilion |
11.5% |
16/139 |
| Thin vermilion border |
10.1% |
14/139 |
| Macrodontia of permanent maxillary central incisor |
8.6% |
12/139 |
| Long philtrum |
7.2% |
10/139 |
| Carious teeth |
6.5% |
9/139 |
| Exaggerated cupid's bow |
6.5% |
9/139 |
| High palate |
6.5% |
9/139 |
| Incisor macrodontia |
5.8% |
8/139 |
| Abnormality of upper lip vermillion |
4.3% |
6/139 |
| Dental crowding |
4.3% |
6/139 |
| Wide mouth |
4.3% |
6/139 |
| Abnormality of dental enamel |
3.6% |
5/139 |
| Abnormality of the teeth |
3.6% |
5/139 |
| Tented upper lip vermilion |
3.6% |
5/139 |
| Thick vermilion border |
3.6% |
5/139 |
| Dental malocclusion |
2.9% |
4/139 |
| Persistence of primary teeth |
2.9% |
4/139 |
| Retrognathia |
2.9% |
4/139 |
| Tented philtrum |
2.9% |
4/139 |
| Thick lower lip vermilion |
2.9% |
4/139 |
| Ankyloglossia |
2.2% |
3/139 |
| High, narrow palate |
2.2% |
3/139 |
| Abnormality of the philtrum |
1.4% |
2/139 |
| Bifid uvula |
1.4% |
2/139 |
| Hypodontia |
1.4% |
2/139 |
| Misalignment of teeth |
1.4% |
2/139 |
| Narrow palate |
1.4% |
2/139 |
| Open bite |
1.4% |
2/139 |
| Tongue thrusting |
1.4% |
2/139 |
| Velopharyngeal insufficiency |
1.4% |
2/139 |
| Abnormality of the maxilla |
0.7% |
1/139 |
| Abnormality of dental morphology |
0.7% |
1/139 |
| Abnormality of the hard palate |
0.7% |
1/139 |
| Abnormality of oral frenula |
0.7% |
1/139 |
| Abnormality of the soft palate |
0.7% |
1/139 |
| Abnormality of the palate |
0.7% |
1/139 |
| Abnormal number of teeth |
0.7% |
1/139 |
| Abnormality of lower lip |
0.7% |
1/139 |
| Abnormal number of permanent teeth |
0.7% |
1/139 |
| Abnormal jaw morphology |
0.7% |
1/139 |
| Broad philtrum |
0.7% |
1/139 |
| Cleft soft palate |
0.7% |
1/139 |
| Deep philtrum |
0.7% |
1/139 |
| Delayed eruption of teeth |
0.7% |
1/139 |
| Dental enamel pits |
0.7% |
1/139 |
| Hypoplasia of teeth |
0.7% |
1/139 |
| Jaw ankylosis |
0.7% |
1/139 |
| Long upper lip |
0.7% |
1/139 |
| Macrotia |
0.7% |
1/139 |
| Micrognathia |
0.7% |
1/139 |
| Narrow jaw |
0.7% |
1/139 |
| Overbite |
0.7% |
1/139 |
| Premature loss of teeth |
0.7% |
1/139 |
| Premature loss of primary teeth |
0.7% |
1/139 |
| Rotated maxillary central incisors |
0.7% |
1/139 |
| Short lingual frenulum |
0.7% |
1/139 |
| Taurodontia |
0.7% |
1/139 |
| Triangular mouth |
0.7% |
1/139 |
| Trismus |
0.7% |
1/139 |
| Unilateral cleft lip |
0.7% |
1/139 |
| U-Shaped upper lip vermilion |
0.7% |
1/139 |
| Yellow-brown discoloration of the teeth |
0.7% |
1/139 |
| Visual and hearing impairments |
|
|
| Abnormal hearing |
49.3% |
69/140 |
| Conductive hearing impairment |
12.9% |
18/140 |
| Hearing impairment |
10.7% |
15/140 |
| Bilateral conductive hearing impairment |
8.6% |
12/140 |
| Abnormality of the Eustachian tube |
2.9% |
4/140 |
| Bilateral sensorineural hearing impairment |
2.9% |
4/140 |
| Hearing abnormality |
2.1% |
3/140 |
| Mixed hearing impairment |
2.1% |
3/140 |
| Otitis media |
2.1% |
3/140 |
| Abnormality of the tympanic membrane |
1.4% |
2/140 |
| Mild hearing impairment |
1.4% |
2/140 |
| Sensorineural hearing impairment |
1.4% |
2/140 |
| Stenosis of the Eustachian tube |
1.4% |
2/140 |
| Apnea |
0.7% |
1/140 |
| Enlarged vestibular aqueduct |
0.7% |
1/140 |
| Impacted cerumen |
0.7% |
1/140 |
| Low-frequency hearing loss |
0.7% |
1/140 |
| Recurrent otitis media |
0.7% |
1/140 |
| Unilateral deafness |
0.7% |
1/140 |
| Abnormal vision |
58.6% |
78/133 |
| Astigmatism |
16.5% |
22/133 |
| Myopia |
15.0% |
20/133 |
| Strabismus |
13.5% |
18/133 |
| Hypermetropia |
11.3% |
15/133 |
| Amblyopia |
7.5% |
10/133 |
| Abnormality of vision |
6.0% |
8/133 |
| Visual impairment |
4.5% |
6/133 |
| Hyperopic astigmatism |
3.0% |
4/133 |
| Anisometropia |
2.3% |
3/133 |
| Nystagmus |
2.3% |
3/133 |
| Blurred vision |
1.5% |
2/133 |
| Unilateral strabismus |
1.5% |
2/133 |
| Cataract |
0.8% |
1/133 |
| Congenital bilateral ptosis |
0.8% |
1/133 |
| Cortical visual impairment |
0.8% |
1/133 |
| Difficulty adjusting from dark to light |
0.8% |
1/133 |
| Esotropia |
0.8% |
1/133 |
| Horizontal nystagmus |
0.8% |
1/133 |
| Intermediate uveitis |
0.8% |
1/133 |
| Peripheral visual field loss |
0.8% |
1/133 |
| Heart |
|
|
| Abnormality of the heart |
26.2% |
37/141 |
| Ventricular septal defect |
9.2% |
13/141 |
| Atria septal defect |
5.7% |
8/141 |
| Patent foramen ovale |
4.3% |
6/141 |
| Heart murmur |
3.5% |
5/141 |
| Abnormality of the mitral valve |
2.1% |
3/141 |
| Aortic aneurysm |
1.4% |
2/141 |
| Bicuspid aortic valve |
1.4% |
2/141 |
| Mitral regurgitation |
1.4% |
2/141 |
| Pericardial effusion |
1.4% |
2/141 |
| Persistent left superior vena cava |
1.4% |
2/141 |
| Abnormality of the coronary arteries |
0.7% |
1/141 |
| Abnormality of the endocardium |
0.7% |
1/141 |
| Abnormality of the atrial septum |
0.7% |
1/141 |
| Abnormal heart morphology |
0.7% |
1/141 |
| Abnormality of the heart valves |
0.7% |
1/141 |
| Abnormality of cardiac atrium |
0.7% |
1/141 |
| Abnormality of the aortic valve |
0.7% |
1/141 |
| Arrhythmia |
0.7% |
1/141 |
| Atrial fibrillation |
0.7% |
1/141 |
| Atrioventricular canal defect |
0.7% |
1/141 |
| Bradycardia |
0.7% |
1/141 |
| Cardiomegaly |
0.7% |
1/141 |
| Cardiac arrest |
0.7% |
1/141 |
| Coarctation of aorta |
0.7% |
1/141 |
| Dilated cardiomyopathy |
0.7% |
1/141 |
| Exercise intolerance |
0.7% |
1/141 |
| Patent ductus arteriosus after birth at term |
0.7% |
1/141 |
| Primum atrial septal defect |
0.7% |
1/141 |
| Sinus tachycardia |
0.7% |
1/141 |
| Tetralogy of Fallot |
0.7% |
1/141 |
| Tetralogy of Fallot with pulmonary stenosis |
0.7% |
1/141 |
| Pulmonary |
|
|
| Abnormality of the lungs |
5.1% |
4/79 |
| Asthma |
3.8% |
3/79 |
| Pulmonary hypoplasia |
1.3% |
1/79 |
| Gastrointestinal |
|
|
| Gastrointestinal abnormalities |
51.7% |
75/145 |
| Feeding difficulties |
26.2% |
38/145 |
| Gastroesophageal reflux |
17.9% |
26/145 |
| Feeding difficulties in infancy |
12.4% |
18/145 |
| Constipation |
8.3% |
12/145 |
| Vomiting |
7.6% |
11/145 |
| Nasogastric tube feeding in infancy |
4.8% |
7/145 |
| Abdominal pain |
3.4% |
5/145 |
| Chronic constipation |
3.4% |
5/145 |
| Episodic vomiting |
3.4% |
5/145 |
| Dysphagia |
2.8% |
4/145 |
| Poor suck |
2.8% |
4/145 |
| Gastrostomy tube feeding in infancy |
2.1% |
3/145 |
| Diarrhea |
1.4% |
2/145 |
| Hiatus hernia |
1.4% |
2/145 |
| Inguinal hernia |
1.4% |
2/145 |
| Projectile vomiting |
1.4% |
2/145 |
| Abdominal colic |
0.7% |
1/145 |
| Abdominal distention |
0.7% |
1/145 |
| Aspiration |
0.7% |
1/145 |
| Bowel urgency |
0.7% |
1/145 |
| Bowel incontinence |
0.7% |
1/145 |
| Celiac disease |
0.7% |
1/145 |
| Chewing difficulties |
0.7% |
1/145 |
| Chronic diarrhea |
0.7% |
1/145 |
| Chylothorax |
0.7% |
1/145 |
| Crohn's disease |
0.7% |
1/145 |
| Delayed self-feeding during toddler years |
0.7% |
1/145 |
| Episodic abdominal pain |
0.7% |
1/145 |
| Esophagitis |
0.7% |
1/145 |
| Exocrine pancreatic insufficiency |
0.7% |
1/145 |
| Food intolerance |
0.7% |
1/145 |
| Gastroparesis |
0.7% |
1/145 |
| Gastrointestinal obstruction |
0.7% |
1/145 |
| Hernia |
0.7% |
1/145 |
| Hypoglycemia |
0.7% |
1/145 |
| Intestinal malrotation |
0.7% |
1/145 |
| Nausea |
0.7% |
1/145 |
| Nausea and vomiting |
0.7% |
1/145 |
| Oral aversion |
0.7% |
1/145 |
| Poor appetite |
0.7% |
1/145 |
| Rectal prolapse |
0.7% |
1/145 |
| Recurrent candida infections |
0.7% |
1/145 |
| Umbilical hernia |
0.7% |
1/145 |
| Weight loss |
0.7% |
1/145 |
| Urogenital |
|
|
| Abnormality of the urogenital system |
30.7% |
42/137 |
| Cryptorchidism |
12.4% |
17/137 |
| Hypospadias |
2.9% |
4/137 |
| Recurrent urinary tract infections |
2.9% |
4/137 |
| Inguinal hernia |
2.2% |
3/137 |
| Abnormality of the renal collecting system |
1.5% |
2/137 |
| Abnormality of the kidney |
1.5% |
2/137 |
| Bilateral cryptorchidism |
1.5% |
2/137 |
| Abnormality of the urethra |
0.7% |
1/137 |
| Abnormality of the bladder |
0.7% |
1/137 |
| Benign prostatic hyperplasia |
0.7% |
1/137 |
| Congenital absence of foreskin |
0.7% |
1/137 |
| Enuresis nocturna |
0.7% |
1/137 |
| Enuresis diurna |
0.7% |
1/137 |
| Enuresis |
0.7% |
1/137 |
| Functional abnormality of the bladder |
0.7% |
1/137 |
| Hydronephrosis |
0.7% |
1/137 |
| Hydrocele testis |
0.7% |
1/137 |
| Infertility |
0.7% |
1/137 |
| Phimosis |
0.7% |
1/137 |
| Pollakisuria |
0.7% |
1/137 |
| Polycystic ovaries |
0.7% |
1/137 |
| Polyuria |
0.7% |
1/137 |
| Testicular torsion |
0.7% |
1/137 |
| Unilateral cryptorchidism |
0.7% |
1/137 |
| Urinary incontinence |
0.7% |
1/137 |
| Vesicoureteral reflux |
0.7% |
1/137 |
| Skeleton |
|
|
| Skeletal abnormalities |
86.1% |
124/144 |
| Pes planus |
18.1% |
26/144 |
| Short stature |
14.6% |
21/144 |
| Clinodactyly of the 5th finger |
13.2% |
19/144 |
| Delayed skeletal maturation |
13.2% |
19/144 |
| Scoliosis |
13.2% |
19/144 |
| Brachydactyly syndrome |
9.0% |
13/144 |
| Brachycephaly |
8.3% |
12/144 |
| Clinodactyly |
6.9% |
10/144 |
| Generalized hypotonia |
5.6% |
8/144 |
| Hip dysplasia |
5.6% |
8/144 |
| Kyphosis |
4.9% |
7/144 |
| Sacral dimple |
4.9% |
7/144 |
| Small hand |
4.9% |
7/144 |
| Large fontanelles |
4.2% |
6/144 |
| Macrocephaly |
4.2% |
6/144 |
| Pectus excavatum |
4.2% |
6/144 |
| Abnormality of the ribs |
3.5% |
5/144 |
| 2-3 toe syndactyly |
3.5% |
5/144 |
| Muscular hypotonia |
2.8% |
4/144 |
| Short 5th finger |
2.8% |
4/144 |
| Abnormality of the hip joint |
2.1% |
3/144 |
| Abnormality of the hand |
2.1% |
3/144 |
| Kyphoscoliosis |
2.1% |
3/144 |
| Microcephaly |
2.1% |
3/144 |
| Mild short stature |
2.1% |
3/144 |
| Plagiocephaly |
2.1% |
3/144 |
| Sandal gap |
2.1% |
3/144 |
| Short foot |
2.1% |
3/144 |
| Toe clinodactyly |
2.1% |
3/144 |
| Abnormality of the thumb |
1.4% |
2/144 |
| Abnormality of the anterior fontanelle |
1.4% |
2/144 |
| Abnormality of the foot |
1.4% |
2/144 |
| Abnormality of the hallux |
1.4% |
2/144 |
| Abnormality of the ankles |
1.4% |
2/144 |
| Achilles tendon contracture |
1.4% |
2/144 |
| Cervical kyphosis |
1.4% |
2/144 |
| Cervical ribs |
1.4% |
2/144 |
| Delayed cranial suture closure |
1.4% |
2/144 |
| Delayed closure of the anterior fontanelle |
1.4% |
2/144 |
| Dysharmonic delayed bone age |
1.4% |
2/144 |
| Flat occiput |
1.4% |
2/144 |
| Generalized osteoporosis |
1.4% |
2/144 |
| Lumbar hyperlordosis |
1.4% |
2/144 |
| Muscular hypotonia of the trunk |
1.4% |
2/144 |
| Osteopenia |
1.4% |
2/144 |
| Severe short stature |
1.4% |
2/144 |
| Single transverse palmar crease |
1.4% |
2/144 |
| Thoracic kyphosis |
1.4% |
2/144 |
| Toe walking |
1.4% |
2/144 |
| Unilateral brachydactyly |
1.4% |
2/144 |
| Wide anterior fontanel |
1.4% |
2/144 |
| Abnormality of the middle phalanx of the 2nd finger |
0.7% |
1/144 |
| Abnormality of the femur |
0.7% |
1/144 |
| Abnormal axial skeleton morphology |
0.7% |
1/144 |
| Abnormal form of the vertebral bodies |
0.7% |
1/144 |
| Abnormal bone ossification |
0.7% |
1/144 |
| Abnormal morphology of bones of the lower limbs |
0.7% |
1/144 |
| Abnormality of the 5th finger |
0.7% |
1/144 |
| Abnormality of the thorax |
0.7% |
1/144 |
| Abnormal joint morphology |
0.7% |
1/144 |
| Abnormality of the vertebrae |
0.7% |
1/144 |
| Abnormality of the palmar creases |
0.7% |
1/144 |
| Abnormality of the middle phalanx of the 5th finger |
0.7% |
1/144 |
| Abnormality of the vertebral endplates |
0.7% |
1/144 |
| Abnormality of the rib cage |
0.7% |
1/144 |
| Abnormality of the vertebral column |
0.7% |
1/144 |
| Abnormal tendon morphology |
0.7% |
1/144 |
| Abnormality of the hip bone |
0.7% |
1/144 |
| Ankle clonus |
0.7% |
1/144 |
| Aplasia/Hypoplasia of the maxilla |
0.7% |
1/144 |
| Aplasia/Hypoplasia of the middle phalanges of the hand |
0.7% |
1/144 |
| Avascular necrosis of the capital femoral epiphysis |
0.7% |
1/144 |
| Back pain |
0.7% |
1/144 |
| Bilateral single transverse palmar creases |
0.7% |
1/144 |
| Bone cyst |
0.7% |
1/144 |
| Broad palm |
0.7% |
1/144 |
| Broad forehead |
0.7% |
1/144 |
| Broad toe |
0.7% |
1/144 |
| Camptodactyly of finger |
0.7% |
1/144 |
| Camptodactyly |
0.7% |
1/144 |
| Central hypotonia |
0.7% |
1/144 |
| Clinodactyly of the 5th toe |
0.7% |
1/144 |
| Congenital hip dislocation |
0.7% |
1/144 |
| Coxa valga |
0.7% |
1/144 |
| Craniosynostosis |
0.7% |
1/144 |
| Curved fingers |
0.7% |
1/144 |
| Dolichocephaly |
0.7% |
1/144 |
| Down-sloping shoulders |
0.7% |
1/144 |
| Finger joint hypermobility |
0.7% |
1/144 |
| Flattened moderately deformed vertebrae |
0.7% |
1/144 |
| Gait ataxia |
0.7% |
1/144 |
| Gait disturbance |
0.7% |
1/144 |
| Hallux varus |
0.7% |
1/144 |
| Hypermobility of toe joints |
0.7% |
1/144 |
| Hyperlordosis |
0.7% |
1/144 |
| Hypocalcemia |
0.7% |
1/144 |
| Increased susceptibility to fractures |
0.7% |
1/144 |
| Intrauterine growth retardation |
0.7% |
1/144 |
| Joint contracture of the hand |
0.7% |
1/144 |
| Limb joint contracture |
0.7% |
1/144 |
| Limited pronation/supination of forearm |
0.7% |
1/144 |
| Lower thoracic kyphosis |
0.7% |
1/144 |
| Lower limb pain |
0.7% |
1/144 |
| Lumbar scoliosis |
0.7% |
1/144 |
| Metatarsus adductus |
0.7% |
1/144 |
| Multiple palmar creases |
0.7% |
1/144 |
| Osteochondritis Dissecans |
0.7% |
1/144 |
| Painless fractures due to injury |
0.7% |
1/144 |
| Patellar dislocation |
0.7% |
1/144 |
| Pectus carinatum |
0.7% |
1/144 |
| Pelvic bone asymmetry |
0.7% |
1/144 |
| Persistent open anterior fontanelle |
0.7% |
1/144 |
| Postaxial hand polydactyly |
0.7% |
1/144 |
| Proportionate short stature |
0.7% |
1/144 |
| Pseudoepiphyses of second metacarpal |
0.7% |
1/144 |
| Sacralization of the fifth lumbar vertebra |
0.7% |
1/144 |
| Scapular winging |
0.7% |
1/144 |
| Short hallux |
0.7% |
1/144 |
| Shortening of all middle phalanges of the fingers |
0.7% |
1/144 |
| Short finger |
0.7% |
1/144 |
| Short toe |
0.7% |
1/144 |
| Short humerus |
0.7% |
1/144 |
| Short digit |
0.7% |
1/144 |
| Short lower limbs |
0.7% |
1/144 |
| Shortening of all distal phalanges of the fingers |
0.7% |
1/144 |
| Short palm |
0.7% |
1/144 |
| Shortening of all proximal phalanges of the fingers |
0.7% |
1/144 |
| Small for gestational age |
0.7% |
1/144 |
| Spina bifida occulta |
0.7% |
1/144 |
| Syndactyly |
0.7% |
1/144 |
| Tapered finger |
0.7% |
1/144 |
| Tethered cord |
0.7% |
1/144 |
| Thoracolumbar scoliosis |
0.7% |
1/144 |
| Tibial torsion |
0.7% |
1/144 |
| Toe syndactyly |
0.7% |
1/144 |
| Trigonocephaly |
0.7% |
1/144 |
| Unsteady gait |
0.7% |
1/144 |
| Upper limb undergrowth |
0.7% |
1/144 |
| Wormian bones |
0.7% |
1/144 |
| Skin / Hair / Nails |
|
|
| Abnormality of the skin/hair/nails |
38.6% |
54/140 |
| Abnormality of the skin |
15.7% |
22/140 |
| Low anterior hairline |
6.4% |
9/140 |
| Single transverse palmar crease |
2.9% |
4/140 |
| Coarse hair |
2.1% |
3/140 |
| Dry skin |
2.1% |
3/140 |
| Dystrophic toenail |
2.1% |
3/140 |
| Eczema |
2.1% |
3/140 |
| Fingernail dysplasia |
2.1% |
3/140 |
| Hyperkeratosis pilaris |
2.1% |
3/140 |
| Macrodontia of permanent maxillary central incisor |
2.1% |
3/140 |
| Cutis marmorata |
1.4% |
2/140 |
| Facial hirsutism |
1.4% |
2/140 |
| Hirsutism |
1.4% |
2/140 |
| Inverted nipples |
1.4% |
2/140 |
| Low posterior hairline |
1.4% |
2/140 |
| Psoriasis |
1.4% |
2/140 |
| Abnormality of dental eruption |
0.7% |
1/140 |
| Abnormality of the palmar creases |
0.7% |
1/140 |
| Abnormality of the scalp |
0.7% |
1/140 |
| Abnormality of the fingernails |
0.7% |
1/140 |
| Abnormality of the frontal hairline |
0.7% |
1/140 |
| Abnormal hair whorl |
0.7% |
1/140 |
| Abnormality of the nipple |
0.7% |
1/140 |
| Abnormality of the nail |
0.7% |
1/140 |
| Absent toenail |
0.7% |
1/140 |
| Acne |
0.7% |
1/140 |
| Atopic dermatitis |
0.7% |
1/140 |
| Atypical scarring of skin |
0.7% |
1/140 |
| Cafe-au-lait spot |
0.7% |
1/140 |
| Cellulitis |
0.7% |
1/140 |
| Clinodactyly of the 5th finger |
0.7% |
1/140 |
| Cyst of the eyelid |
0.7% |
1/140 |
| Dental malocclusion |
0.7% |
1/140 |
| Fine hair |
0.7% |
1/140 |
| Frontal upsweep of hair |
0.7% |
1/140 |
| Hypertrichosis |
0.7% |
1/140 |
| Increased number of teeth |
0.7% |
1/140 |
| Multiple plantar creases |
0.7% |
1/140 |
| Nevus |
0.7% |
1/140 |
| Prominent eyelashes |
0.7% |
1/140 |
| Recurrent fungal infections |
0.7% |
1/140 |
| Sacral dimple |
0.7% |
1/140 |
| Small nail |
0.7% |
1/140 |
| Sparse hair |
0.7% |
1/140 |
| Sparse anterior scalp hair |
0.7% |
1/140 |
| Thick hair |
0.7% |
1/140 |
| Thin skin |
0.7% |
1/140 |
| Umbilical hernia |
0.7% |
1/140 |
| Urticaria |
0.7% |
1/140 |
| Vitiligo |
0.7% |
1/140 |
| Endocrine / Immunological / Metabolic |
|
|
| Abnormality of the endocrine system |
13.3% |
18/135 |
| Growth hormone deficiency |
4.4% |
6/135 |
| Precocious puberty in females |
1.5% |
2/135 |
| Abnormal glucose homeostasis |
0.7% |
1/135 |
| Abnormality of folate metabolism |
0.7% |
1/135 |
| Adrenal insufficiency |
0.7% |
1/135 |
| Decreased serum insulin-like growth factor 1 |
0.7% |
1/135 |
| Diabetes mellitus |
0.7% |
1/135 |
| Dysharmonic delayed bone age |
0.7% |
1/135 |
| Facial hirsutism |
0.7% |
1/135 |
| Fatigue |
0.7% |
1/135 |
| Generalized osteoporosis |
0.7% |
1/135 |
| Generalized hirsutism |
0.7% |
1/135 |
| Hirsutism |
0.7% |
1/135 |
| Hyperglycemia |
0.7% |
1/135 |
| Hypoglycemia |
0.7% |
1/135 |
| Hypohidrotic ectodermal dysplasia |
0.7% |
1/135 |
| Increased circulating ACTH level |
0.7% |
1/135 |
| Juvenile rheumatoid arthritis |
0.7% |
1/135 |
| Menstrual irregularities |
0.7% |
1/135 |
| Neonatal hypoglycemia |
0.7% |
1/135 |
| Polydipsia |
0.7% |
1/135 |
| Polyuria |
0.7% |
1/135 |
| Short stature |
0.7% |
1/135 |
| Small pituitary gland |
0.7% |
1/135 |
| Thyroid-stimulating hormone excess |
0.7% |
1/135 |
| Abnormality of the metabolic system |
20.0% |
28/140 |
| Slender build |
4.3% |
6/140 |
| Abnormality of temperature regulation |
3.6% |
5/140 |
| Failure to thrive |
2.9% |
4/140 |
| Pain insensitivity |
2.9% |
4/140 |
| Sleep disturbance |
2.9% |
4/140 |
| Chronic fatigue |
2.1% |
3/140 |
| Failure to thrive in infancy |
2.1% |
3/140 |
| Impaired pain sensation |
2.1% |
3/140 |
| Abnormality of body weight |
1.4% |
2/140 |
| Anemia |
1.4% |
2/140 |
| Apnea |
1.4% |
2/140 |
| Abnormality of copper homeostasis |
0.7% |
1/140 |
| Abnormality of alkaline phosphatase activity |
0.7% |
1/140 |
| Abnormal platelet function |
0.7% |
1/140 |
| Abnormality of pain sensation |
0.7% |
1/140 |
| Absence of subcutaneous fat |
0.7% |
1/140 |
| Aspiration |
0.7% |
1/140 |
| Asthma |
0.7% |
1/140 |
| Bruising susceptibility |
0.7% |
1/140 |
| Congenital diaphragmatic hernia |
0.7% |
1/140 |
| Cyanotic episode |
0.7% |
1/140 |
| Edema |
0.7% |
1/140 |
| Erythrocyte macrocytosis |
0.7% |
1/140 |
| Generalized edema |
0.7% |
1/140 |
| Hamstring contractures |
0.7% |
1/140 |
| Hyperbilirubinemia |
0.7% |
1/140 |
| Impaired temperature sensation |
0.7% |
1/140 |
| Inguinal hernia |
0.7% |
1/140 |
| Iron deficiency anemia |
0.7% |
1/140 |
| Jaundice |
0.7% |
1/140 |
| Neonatal respiratory distress |
0.7% |
1/140 |
| Postnatal growth retardation |
0.7% |
1/140 |
| Prolonged neonatal jaundice |
0.7% |
1/140 |
| Pulmonary edema |
0.7% |
1/140 |
| Reduced factor VII activity |
0.7% |
1/140 |
| Sleep apnea |
0.7% |
1/140 |
| Small for gestational age |
0.7% |
1/140 |
| Umbilical hernia |
0.7% |
1/140 |
| Weight loss |
0.7% |
1/140 |
| Abnormality of the immune system |
17.2% |
23/134 |
| Allergy |
3.0% |
4/134 |
| Recurrent otitis media |
3.0% |
4/134 |
| Recurrent infections in infancy and early childhood |
1.5% |
2/134 |
| Recurrent sinusitis |
1.5% |
2/134 |
| Sinusitis |
1.5% |
2/134 |
| Abnormal size of nasopharyngeal adenoids |
0.7% |
1/134 |
| Abnormality of cellular immune system |
0.7% |
1/134 |
| Abnormality of T cells |
0.7% |
1/134 |
| Abnormality of B cells |
0.7% |
1/134 |
| Abnormal immunoglobulin level |
0.7% |
1/134 |
| Allergic rhinitis |
0.7% |
1/134 |
| Celiac disease |
0.7% |
1/134 |
| Cellular immunodeficiency |
0.7% |
1/134 |
| Chronic sinusitis |
0.7% |
1/134 |
| Cow milk allergy |
0.7% |
1/134 |
| Episodic fever |
0.7% |
1/134 |
| Esophagitis |
0.7% |
1/134 |
| Immunodeficiency |
0.7% |
1/134 |
| Increased size of nasopharyngeal adenoids |
0.7% |
1/134 |
| Juvenile rheumatoid arthritis |
0.7% |
1/134 |
| Leukopenia |
0.7% |
1/134 |
| Lymphopenia |
0.7% |
1/134 |
| Pancytopenia |
0.7% |
1/134 |
| Pneumonia |
0.7% |
1/134 |
| Psoriasis |
0.7% |
1/134 |
| Recurrent infections |
0.7% |
1/134 |
| Recurrent upper respiratory tract infections |
0.7% |
1/134 |
| Rheumatoid arthritis |
0.7% |
1/134 |
| Seasonal allergy |
0.7% |
1/134 |