Patient Overview : 16

General

Frequency of all clinical findings

Percentage Cases
Gender    
Male 68.8% 11/16
Female 31.3% 5/16
General    
Birth Length abnormalities 0% 0/16
Birth Weight abnormalities 0% 0/16
Birth Head circumference abnormalities 0% 0/16
Current Height abnormalities 0% 0/16
Current Weight abnormalities 0% 0/16
Current Head circumference abnormalities 0% 0/16
Neurology    
Neurological abnormalities 100.0% 16/16
Global developmental delay 56.3% 9/16
Areflexia of lower limbs 37.5% 6/16
Impaired pain sensation 31.3% 5/16
Generalized-onset seizure 25.0% 4/16
Hypertonia 18.8% 3/16
Reduced tendon reflexes 12.5% 2/16
Status epilepticus 12.5% 2/16
Absent speech 6.3% 1/16
Ankle clonus 6.3% 1/16
Areflexia 6.3% 1/16
Autism 6.3% 1/16
Babinski sign 6.3% 1/16
Distal muscle weakness 6.3% 1/16
Gait imbalance 6.3% 1/16
Gait disturbance 6.3% 1/16
Muscle stiffness 6.3% 1/16
obsolete Distal sensory loss of all modalities 6.3% 1/16
Progressive muscle weakness 6.3% 1/16
Seizure 6.3% 1/16
Somatic sensory dysfunction 6.3% 1/16
Steppage gait 6.3% 1/16
Behavioral problems 77.8% 7/9
Hyperactivity 33.3% 3/9
Autistic behavior 22.2% 2/9
Sleep disturbance 22.2% 2/9
Autism 11.1% 1/9
Self-mutilation 11.1% 1/9
Self-biting 11.1% 1/9
Brain abnormality 55.6% 5/9
CNS hypomyelination 22.2% 2/9
Abnormal CNS myelination 11.1% 1/9
Chiari type I malformation 11.1% 1/9
CNS demyelination 11.1% 1/9
Hydrocephalus 11.1% 1/9
Mild fetal ventriculomegaly 11.1% 1/9
Visual and hearing impairments    
Abnormal hearing 50.0% 1/2
Severe sensorineural hearing impairment 50.0% 1/2
Pulmonary    
Abnormality of the lungs 25.0% 1/4
Asthma 25.0% 1/4
Gastrointestinal    
Gastrointestinal abnormalities 75.0% 3/4
Gastroesophageal reflux 50.0% 2/4
Constipation 25.0% 1/4
Skeleton    
Skeletal abnormalities 91.7% 11/12
Distal lower limb amyotrophy 50.0% 6/12
Distal lower limb muscle weakness 50.0% 6/12
Distal upper limb muscle weakness 50.0% 6/12
Distal upper limb amyotrophy 50.0% 6/12
Pes planus 16.7% 2/12
Skeletal muscle atrophy 16.7% 2/12
Distal muscle weakness 8.3% 1/12
Pes valgus 8.3% 1/12
Scoliosis 8.3% 1/12
Talipes equinovarus 8.3% 1/12