The FERM domain-containing protein 5 (FRMD5 [OMIM: 616309]) is localized to adherens junctions. Previous studies have documented that knockdown of FRMD5 promotes lung cancer cell migration and invasion. FRMD5 inhibits migration through binding to integrin subunit beta 5 (ITGB5) and Rho-associated coiled-coil-containing protein kinase 1 (ROCK1). However, other scientists showed that knockdown of FRMD5 suppresses hepatocellular carcinoma cell (HCC) proliferation and tumorigenesis and that FRMD5 is elevated by Wnt/β-catenin activation in human HCCs. In addition, the transcriptional activity of FRMD5 is regulated by β-catenin in colorectal cancer cells. These data indicate different functional outcomes of loss of FRMD5 in different contexts.
FRMD5