Parents

Clinical features
Mutations in the KIF26A gene may cause an autosomal recessive syndrome, characterized by neurological and gastrointestinal (GI) involvement.

Prevalence
The prevalence is not known, with around 10 cases reported to date.

Inheritance
Mutations of this gene can be passed on to the next generation in an autosomal recessive manner. This means that if both parents carry a mutation involving this gene (usually without displaying the disease), there is a greater chance that their children are going to inherit the mutations from both parents and display the disease. This is especially important to consider in consanguineous marriage, where the chance of both parents having the same mutation and passing it is greater.