Management

While monosaccharide or cofactor supplementation is effective in glycosylation and clinical presentation, currently, there's no effective treatment for MAN1B1-CDG. Treatment is usually supportive, including occupational therapy, physical therapy, and speech therapy. Several supportive care measures and treatment options can significantly improve a child's quality of life and manage symptoms.  For some children with feeding difficulties due to poor oral motor skills, placing a nasogastric or gastrostomy tube may be necessary. These tubes provide direct access to the stomach or small intestine, ensuring adequate nutrition and hydration. Consultation with a hematologist is crucial to assess the coagulation status. Orthopedic management involves physical medicine management, wheelchairs, transfer devices, and physical therapy. Surgical treatment of kyphoscoliosis may be needed.