The PRICKLE1 gene provides instructions for making a protein called prickle homolog 1. This protein is a regulator in the development of the nervous system, before birth. Indeed prickle homolog 1 is probably part of a chemical signaling pathway (Wnt noncanonical planar cell polarity pathway), which supports the positioning of the various components of cells and regulates the movements of nerve cells (neurons) during the development of the brain and the nervous system. Prickle homolog 1 probably works together with other proteins preventing the REST protein from entering in the cell nucleus and then binding particular regions of DNA. This interaction between Prickle homolog 1 and REST protein contributes to the normal development of the nervous system.
The PRICKLE1 gene can also sometimes be associated with other names such as EPM1B (Epilepsy Progressive Myoclonic 1B), FLJ31937, REST/NRSF-interacting LIM domain protein, or RILP.
PRICKLE1