SON
| Percentage | Cases | |
|---|---|---|
| Gender | ||
| Male | 50.9% | 27/53 |
| Female | 49.1% | 26/53 |
| Indifferent | 0% | 0/53 |
| Unknown | 0% | 0/53 |
| General | ||
| Birth Length abnormalities | 1.9% | 1/53 |
| < P3 : Birth length less than 3rd percentile | 1.9% | 1/53 |
| Birth Weight abnormalities | 22.6% | 12/53 |
| < P3 : Small for gestational age | 22.6% | 12/53 |
| Birth Head circumference abnormalities | 1.9% | 1/53 |
| < P3 : Congenital microcephaly | 1.9% | 1/53 |
| Current Height abnormalities | 50.9% | 27/53 |
| < P3 : Short stature | 50.9% | 27/53 |
| Current Weight abnormalities | 30.2% | 16/53 |
| < P3 : Decreased body weight | 28.3% | 15/53 |
| > P98 : Increased body weight | 1.9% | 1/53 |
| Current Head circumference abnormalities | 24.5% | 13/53 |
| < P3 : Microcephaly | 22.6% | 12/53 |
| > P98 : Macrocephaly | 1.9% | 1/53 |
| Neurology | ||
| Neurological abnormalities | 90.2% | 46/51 |
| Generalized hypotonia | 47.1% | 24/51 |
| Seizures | 19.6% | 10/51 |
| Global developmental delay | 15.7% | 8/51 |
| EEG abnormality | 11.8% | 6/51 |
| Developmental regression | 7.8% | 4/51 |
| Febrile seizures | 7.8% | 4/51 |
| Focal seizures with impairment of consciousness or awareness | 7.8% | 4/51 |
| Absence seizures | 5.9% | 3/51 |
| Generalized tonic-clonic seizures | 5.9% | 3/51 |
| Neonatal hypotonia | 5.9% | 3/51 |
| Complex febrile seizures | 3.9% | 2/51 |
| EEG with abnormally slow frequencies | 3.9% | 2/51 |
| Gait disturbance | 3.9% | 2/51 |
| Generalized neonatal hypotonia | 3.9% | 2/51 |
| Neurodevelopmental delay | 3.9% | 2/51 |
| Severe muscular hypotonia | 3.9% | 2/51 |
| Severe global developmental delay | 3.9% | 2/51 |
| Status epilepticus | 3.9% | 2/51 |
| Toe walking | 3.9% | 2/51 |
| Unsteady gait | 3.9% | 2/51 |
| Abnormality of coordination | 2.0% | 1/51 |
| Central hypotonia | 2.0% | 1/51 |
| Decreased patellar reflex | 2.0% | 1/51 |
| Difficulty standing | 2.0% | 1/51 |
| Dystonia | 2.0% | 1/51 |
| EEG with focal sharp waves | 2.0% | 1/51 |
| EEG with central focal spikes | 2.0% | 1/51 |
| EEG with occipital slowing | 2.0% | 1/51 |
| EEG with focal slow activity | 2.0% | 1/51 |
| EEG with intermittent slow activity | 2.0% | 1/51 |
| EMG abnormality | 2.0% | 1/51 |
| Focal seizures | 2.0% | 1/51 |
| Hemiparesis | 2.0% | 1/51 |
| Hypertonia | 2.0% | 1/51 |
| Impaired pain sensation | 2.0% | 1/51 |
| Infantile muscular hypotonia | 2.0% | 1/51 |
| Muscular hypotonia of the trunk | 2.0% | 1/51 |
| Muscular hypotonia | 2.0% | 1/51 |
| Nystagmus | 2.0% | 1/51 |
| Peripheral demyelination | 2.0% | 1/51 |
| Polyneuropathy | 2.0% | 1/51 |
| Postural instability | 2.0% | 1/51 |
| Severe neonatal hypotonia in males | 2.0% | 1/51 |
| Shuffling gait | 2.0% | 1/51 |
| Spastic diplegia | 2.0% | 1/51 |
| Spastic tetraplegia | 2.0% | 1/51 |
| Spasticity | 2.0% | 1/51 |
| Behavioral problems | 56.3% | 27/48 |
| Sleep disturbance | 18.8% | 9/48 |
| Behavioral abnormality | 14.6% | 7/48 |
| Autism | 10.4% | 5/48 |
| Autistic behavior | 6.3% | 3/48 |
| Insomnia | 6.3% | 3/48 |
| Self-injurious behavior | 6.3% | 3/48 |
| Short attention span | 6.3% | 3/48 |
| Aggressive behavior | 4.2% | 2/48 |
| Hyperactivity | 4.2% | 2/48 |
| Repetitive compulsive behavior | 4.2% | 2/48 |
| Stereotypic behavior | 4.2% | 2/48 |
| Abnormal aggressive, impulsive or violent behavior | 2.1% | 1/48 |
| Anxiety | 2.1% | 1/48 |
| Auditory hallucinations | 2.1% | 1/48 |
| Hyperacusis | 2.1% | 1/48 |
| Impaired social interactions | 2.1% | 1/48 |
| Low frustration tolerance | 2.1% | 1/48 |
| Poor eye contact | 2.1% | 1/48 |
| Recurrent hand flapping | 2.1% | 1/48 |
| Restlessness | 2.1% | 1/48 |
| Brain abnormality | 82.2% | 37/45 |
| Ventriculomegaly | 42.2% | 19/45 |
| Abnormality of the corpus callosum | 22.2% | 10/45 |
| Cortical dysplasia | 15.6% | 7/45 |
| Hypoplasia of the corpus callosum | 15.6% | 7/45 |
| Abnormality of the cerebral white matter | 11.1% | 5/45 |
| Abnormality of the cerebellum | 8.9% | 4/45 |
| Widened subarachnoid space | 8.9% | 4/45 |
| Cavum septum pellucidum | 6.7% | 3/45 |
| Dilation of lateral ventricles | 6.7% | 3/45 |
| Extra-axial cerebrospinal fluid accumulation | 6.7% | 3/45 |
| Gliosis | 6.7% | 3/45 |
| Perisylvian polymicrogyria | 6.7% | 3/45 |
| Polymicrogyria | 6.7% | 3/45 |
| Abnormality of lateral ventricle | 4.4% | 2/45 |
| Abnormality of the fourth ventricle | 4.4% | 2/45 |
| Arachnoid cyst | 4.4% | 2/45 |
| Cerebellar hypoplasia | 4.4% | 2/45 |
| Heterotopia | 4.4% | 2/45 |
| Hydrocephalus | 4.4% | 2/45 |
| Periventricular gray matter heterotopia | 4.4% | 2/45 |
| Abnormality of the third ventricle | 2.2% | 1/45 |
| Abnormality of the cerebrum | 2.2% | 1/45 |
| Abnormality of the cerebral cortex | 2.2% | 1/45 |
| Abnormality of the periventricular white matter | 2.2% | 1/45 |
| Arnold-Chiari malformation | 2.2% | 1/45 |
| Asymmetric ventricles | 2.2% | 1/45 |
| Brain atrophy | 2.2% | 1/45 |
| Cerebral atrophy | 2.2% | 1/45 |
| Communicating hydrocephalus | 2.2% | 1/45 |
| Cortical gyral simplification | 2.2% | 1/45 |
| Delayed CNS myelination | 2.2% | 1/45 |
| Dysplastic corpus callosum | 2.2% | 1/45 |
| Enlarged fetal cisterna magna | 2.2% | 1/45 |
| Enlarged cisterna magna | 2.2% | 1/45 |
| Ischemic stroke | 2.2% | 1/45 |
| Limbic malformations | 2.2% | 1/45 |
| Morphological abnormality of the central nervous system | 2.2% | 1/45 |
| Multifocal cerebral white matter abnormalities | 2.2% | 1/45 |
| Noncommunicating hydrocephalus | 2.2% | 1/45 |
| Optic nerve hypoplasia | 2.2% | 1/45 |
| Periventricular leukomalacia | 2.2% | 1/45 |
| Progressive ventriculomegaly | 2.2% | 1/45 |
| Small posterior fossa | 2.2% | 1/45 |
| Transient ischemic attack | 2.2% | 1/45 |
| Facial abnormalities | ||
| Abnormality of the ear | 69.8% | 30/43 |
| Low-set ears | 48.8% | 21/43 |
| Posteriorly rotated ears | 11.6% | 5/43 |
| Abnormality of the pinna | 4.7% | 2/43 |
| Macrotia | 4.7% | 2/43 |
| Protruding ear | 4.7% | 2/43 |
| Abnormality of earlobe | 2.3% | 1/43 |
| Hypoplastic helices | 2.3% | 1/43 |
| Low-set, posteriorly rotated ears | 2.3% | 1/43 |
| Microtia | 2.3% | 1/43 |
| Abnormality of the eye | 95.7% | 45/47 |
| Downslanted palpebral fissures | 48.9% | 23/47 |
| Strabismus | 44.7% | 21/47 |
| Deeply set eye | 25.5% | 12/47 |
| Epicanthus | 19.1% | 9/47 |
| Hypertelorism | 10.6% | 5/47 |
| Esotropia | 8.5% | 4/47 |
| Exotropia | 4.3% | 2/47 |
| Long palpebral fissure | 4.3% | 2/47 |
| Prominent epicanthal folds | 4.3% | 2/47 |
| Abnormality of eye movement | 2.1% | 1/47 |
| Aplasia/Hypoplasia affecting the eye | 2.1% | 1/47 |
| Cleft eyelid | 2.1% | 1/47 |
| Horizontal eyebrow | 2.1% | 1/47 |
| Proptosis | 2.1% | 1/47 |
| Sparse lateral eyebrow | 2.1% | 1/47 |
| Synophrys | 2.1% | 1/47 |
| Unilateral ptosis | 2.1% | 1/47 |
| Upslanted palpebral fissure | 2.1% | 1/47 |
| Abnormality of the nose | 71.4% | 30/42 |
| Abnormality of the nasal bridge | 28.6% | 12/42 |
| Wide nasal bridge | 14.3% | 6/42 |
| Depressed nasal bridge | 11.9% | 5/42 |
| Short nose | 9.5% | 4/42 |
| Bulbous nose | 7.1% | 3/42 |
| Underdeveloped nasal alae | 4.8% | 2/42 |
| Abnormality of the nares | 2.4% | 1/42 |
| Abnormality of the nasolabial region | 2.4% | 1/42 |
| Broad nasal tip | 2.4% | 1/42 |
| Convex nasal ridge | 2.4% | 1/42 |
| Flared nostrils | 2.4% | 1/42 |
| Low hanging columella | 2.4% | 1/42 |
| Prominent nose | 2.4% | 1/42 |
| Wide nasal base | 2.4% | 1/42 |
| Abnormality of the mouth | 73.8% | 31/42 |
| Short philtrum | 42.9% | 18/42 |
| Thin upper lip vermilion | 14.3% | 6/42 |
| Downturned corners of mouth | 11.9% | 5/42 |
| Narrow mouth | 9.5% | 4/42 |
| Smooth philtrum | 9.5% | 4/42 |
| Bifid uvula | 4.8% | 2/42 |
| Cleft palate | 4.8% | 2/42 |
| Thin vermilion border | 4.8% | 2/42 |
| Abnormality of the maxilla | 2.4% | 1/42 |
| Ankyloglossia | 2.4% | 1/42 |
| Everted lower lip vermilion | 2.4% | 1/42 |
| High palate | 2.4% | 1/42 |
| Long philtrum | 2.4% | 1/42 |
| Open mouth | 2.4% | 1/42 |
| Overbite | 2.4% | 1/42 |
| Thick vermilion border | 2.4% | 1/42 |
| Thick lower lip vermilion | 2.4% | 1/42 |
| Thin lower lip vermilion | 2.4% | 1/42 |
| Visual and hearing impairments | ||
| Abnormal hearing | 16.0% | 8/50 |
| Bilateral sensorineural hearing impairment | 4.0% | 2/50 |
| Hearing impairment | 4.0% | 2/50 |
| Mild hearing impairment | 4.0% | 2/50 |
| Bilateral conductive hearing impairment | 2.0% | 1/50 |
| Hearing abnormality | 2.0% | 1/50 |
| Abnormal vision | 42.9% | 21/49 |
| Hypermetropia | 18.4% | 9/49 |
| Cortical visual impairment | 10.2% | 5/49 |
| Myopia | 8.2% | 4/49 |
| Astigmatism | 6.1% | 3/49 |
| High-grade hypermetropia | 4.1% | 2/49 |
| Abnormality of vision | 2.0% | 1/49 |
| Abnormal eye physiology | 2.0% | 1/49 |
| Amblyopia | 2.0% | 1/49 |
| Blue sclerae | 2.0% | 1/49 |
| Optic nerve hypoplasia | 2.0% | 1/49 |
| Progressive visual loss | 2.0% | 1/49 |
| Reduced visual acuity | 2.0% | 1/49 |
| Severe photosensitivity | 2.0% | 1/49 |
| Slow saccadic eye movements | 2.0% | 1/49 |
| Heart | ||
| Abnormality of the heart | 32.7% | 16/49 |
| Ventricular septal defect | 10.2% | 5/49 |
| Hypertension | 8.2% | 4/49 |
| Atria septal defect | 6.1% | 3/49 |
| Secundum atrial septal defect | 4.1% | 2/49 |
| Abnormal branching pattern of the aortic arch | 2.0% | 1/49 |
| Abnormal heart morphology | 2.0% | 1/49 |
| Abnormality of cardiovascular system physiology | 2.0% | 1/49 |
| Abnormality of the systemic arterial tree | 2.0% | 1/49 |
| Arrhythmia | 2.0% | 1/49 |
| Bicuspid aortic valve | 2.0% | 1/49 |
| Dysplastic aortic valve | 2.0% | 1/49 |
| Heart murmur | 2.0% | 1/49 |
| Hypoplastic left heart | 2.0% | 1/49 |
| Patent ductus arteriosus after birth at term | 2.0% | 1/49 |
| Patent ductus arteriosus | 2.0% | 1/49 |
| Patent foramen ovale | 2.0% | 1/49 |
| Primum atrial septal defect | 2.0% | 1/49 |
| Gastrointestinal | ||
| Gastrointestinal abnormalities | 70.8% | 34/48 |
| Feeding difficulties in infancy | 37.5% | 18/48 |
| Feeding difficulties | 27.1% | 13/48 |
| Dysphagia | 10.4% | 5/48 |
| Gastrostomy tube feeding in infancy | 10.4% | 5/48 |
| Gastroesophageal reflux | 10.4% | 5/48 |
| Constipation | 8.3% | 4/48 |
| Duodenal atresia | 4.2% | 2/48 |
| Gastroparesis | 4.2% | 2/48 |
| Intestinal malrotation | 4.2% | 2/48 |
| Nasogastric tube feeding in infancy | 4.2% | 2/48 |
| Poor suck | 4.2% | 2/48 |
| Abnormal eating behavior | 2.1% | 1/48 |
| Abnormality of the duodenum | 2.1% | 1/48 |
| Absent gallbladder | 2.1% | 1/48 |
| Chronic diarrhea | 2.1% | 1/48 |
| Diarrhea | 2.1% | 1/48 |
| Exocrine pancreatic insufficiency | 2.1% | 1/48 |
| Gastrointestinal dysmotility | 2.1% | 1/48 |
| Hypoplasia of the gallbladder | 2.1% | 1/48 |
| Nausea and vomiting | 2.1% | 1/48 |
| Oral-pharyngeal dysphagia | 2.1% | 1/48 |
| Poor appetite | 2.1% | 1/48 |
| Umbilical hernia | 2.1% | 1/48 |
| Vomiting | 2.1% | 1/48 |
| Urogenital | ||
| Abnormality of the urogenital system | 44.9% | 22/49 |
| Horseshoe kidney | 12.2% | 6/49 |
| Multiple renal cysts | 6.1% | 3/49 |
| Multicystic kidney dysplasia | 4.1% | 2/49 |
| Abnormal renal morphology | 2.0% | 1/49 |
| Bilateral renal hypoplasia | 2.0% | 1/49 |
| Cryptorchidism | 2.0% | 1/49 |
| Enlarged kidneys | 2.0% | 1/49 |
| Hydronephrosis | 2.0% | 1/49 |
| Hypoplastic labia majora | 2.0% | 1/49 |
| Hypoplasia of the ovary | 2.0% | 1/49 |
| Hypoplasia of the uterus | 2.0% | 1/49 |
| Inguinal hernia | 2.0% | 1/49 |
| Nephrocalcinosis | 2.0% | 1/49 |
| Polyuria | 2.0% | 1/49 |
| Renal hypoplasia | 2.0% | 1/49 |
| Renal malrotation | 2.0% | 1/49 |
| Renal dysplasia | 2.0% | 1/49 |
| Shawl scrotum | 2.0% | 1/49 |
| Solitary renal cyst | 2.0% | 1/49 |
| Unilateral cryptorchidism | 2.0% | 1/49 |
| Unilateral renal atrophy | 2.0% | 1/49 |
| Unilateral renal agenesis | 2.0% | 1/49 |
| Unilateral renal hypoplasia | 2.0% | 1/49 |
| Uric acid urolithiasis independent of gout | 2.0% | 1/49 |
| Vesicoureteral reflux | 2.0% | 1/49 |
| Skeleton | ||
| Skeletal abnormalities | 82.0% | 41/50 |
| Joint hypermobility | 26.0% | 13/50 |
| Pes planus | 20.0% | 10/50 |
| Short foot | 10.0% | 5/50 |
| Abnormality of the curvature of the vertebral column | 8.0% | 4/50 |
| Delayed skeletal maturation | 6.0% | 3/50 |
| Hip dysplasia | 6.0% | 3/50 |
| Joint laxity | 6.0% | 3/50 |
| Sagittal craniosynostosis | 6.0% | 3/50 |
| Short toe | 6.0% | 3/50 |
| Abnormality of limbs | 4.0% | 2/50 |
| Cervical ribs | 4.0% | 2/50 |
| Dolichocephaly | 4.0% | 2/50 |
| Finger joint hypermobility | 4.0% | 2/50 |
| Flexion contracture | 4.0% | 2/50 |
| Genu valgum | 4.0% | 2/50 |
| Hemivertebrae | 4.0% | 2/50 |
| Hyperextensibility at elbow | 4.0% | 2/50 |
| Hypertrophy of the lower limb | 4.0% | 2/50 |
| Long fingers | 4.0% | 2/50 |
| Short finger | 4.0% | 2/50 |
| Short distal phalanx of finger | 4.0% | 2/50 |
| Abnormality of the hip bone | 2.0% | 1/50 |
| Abnormality of the femoral neck | 2.0% | 1/50 |
| Abnormality of the hip joint | 2.0% | 1/50 |
| Abnormality of the thorax | 2.0% | 1/50 |
| Abnormality of the foot | 2.0% | 1/50 |
| Abnormality of the thumb | 2.0% | 1/50 |
| Absent thumb | 2.0% | 1/50 |
| Aplasia/Hypoplasia of the 4th toe | 2.0% | 1/50 |
| Aplasia/Hypoplasia of the thumb | 2.0% | 1/50 |
| Arachnodactyly | 2.0% | 1/50 |
| Aseptic necrosis | 2.0% | 1/50 |
| Avascular necrosis of the capital femoral epiphysis | 2.0% | 1/50 |
| Bilateral talipes equinovarus | 2.0% | 1/50 |
| Brachydactyly syndrome | 2.0% | 1/50 |
| Camptodactyly of finger | 2.0% | 1/50 |
| Clinodactyly of the 5th finger | 2.0% | 1/50 |
| Clinodactyly | 2.0% | 1/50 |
| Craniosynostosis | 2.0% | 1/50 |
| Cubitus valgus | 2.0% | 1/50 |
| Disproportionate short-trunk short stature | 2.0% | 1/50 |
| Disproportionate tall stature | 2.0% | 1/50 |
| Distal arthrogryposis | 2.0% | 1/50 |
| Generalized osteoporosis | 2.0% | 1/50 |
| Hypermobility of interphalangeal joints | 2.0% | 1/50 |
| Hypertrophy of the upper limb | 2.0% | 1/50 |
| Hyperlordosis | 2.0% | 1/50 |
| Hypoplasia of the maxilla | 2.0% | 1/50 |
| Increased arm span | 2.0% | 1/50 |
| Kyphoscoliosis | 2.0% | 1/50 |
| Lumbar hyperlordosis | 2.0% | 1/50 |
| Osteoporosis | 2.0% | 1/50 |
| Pectus excavatum | 2.0% | 1/50 |
| Plagiocephaly | 2.0% | 1/50 |
| Proximal placement of thumb | 2.0% | 1/50 |
| Reduced bone mineral density | 2.0% | 1/50 |
| Rib fusion | 2.0% | 1/50 |
| Scoliosis | 2.0% | 1/50 |
| Skeletal muscle atrophy | 2.0% | 1/50 |
| Slender finger | 2.0% | 1/50 |
| Small hand | 2.0% | 1/50 |
| Small posterior fossa | 2.0% | 1/50 |
| Small finger | 2.0% | 1/50 |
| Structural foot deformity | 2.0% | 1/50 |
| Syndactyly | 2.0% | 1/50 |
| Talipes equinovarus | 2.0% | 1/50 |
| Tapered finger | 2.0% | 1/50 |
| Thoracic hemivertebrae | 2.0% | 1/50 |
| Trigonocephaly | 2.0% | 1/50 |
| Unicoronal synostosis | 2.0% | 1/50 |
| Valgus foot deformity | 2.0% | 1/50 |
| Vertebral fusion | 2.0% | 1/50 |
| 2-3 toe syndactyly | 2.0% | 1/50 |
| Skin / Hair / Nails | ||
| Abnormality of the skin/hair/nails | 44.0% | 22/50 |
| Sacral dimple | 10.0% | 5/50 |
| Prominent fingertip pads | 8.0% | 4/50 |
| Abnormality of the toenails | 6.0% | 3/50 |
| Curly hair | 6.0% | 3/50 |
| Single transverse palmar crease | 6.0% | 3/50 |
| Abnormality of dental enamel | 4.0% | 2/50 |
| Carious teeth | 4.0% | 2/50 |
| Fair hair | 4.0% | 2/50 |
| Fine hair | 4.0% | 2/50 |
| Hyperconvex nail | 4.0% | 2/50 |
| Jaundice | 4.0% | 2/50 |
| Soft, doughy skin | 4.0% | 2/50 |
| Abnormality of the hairline | 2.0% | 1/50 |
| Abnormality of skin morphology | 2.0% | 1/50 |
| Abnormal subcutaneous fat tissue distribution | 2.0% | 1/50 |
| Abnormality of the teeth | 2.0% | 1/50 |
| Blue nevus | 2.0% | 1/50 |
| Bruising susceptibility | 2.0% | 1/50 |
| Concave nail | 2.0% | 1/50 |
| Decreased palmar creases | 2.0% | 1/50 |
| Dermal translucency | 2.0% | 1/50 |
| Dystrophic toenail | 2.0% | 1/50 |
| Ectodermal dysplasia | 2.0% | 1/50 |
| Generalized hypoplasia of dental enamel | 2.0% | 1/50 |
| Grayish enamel | 2.0% | 1/50 |
| Hyperkeratosis | 2.0% | 1/50 |
| Hyperextensible skin | 2.0% | 1/50 |
| Incisor macrodontia | 2.0% | 1/50 |
| Inguinal freckling | 2.0% | 1/50 |
| Low anterior hairline | 2.0% | 1/50 |
| Melanonychia | 2.0% | 1/50 |
| Microdontia | 2.0% | 1/50 |
| Multiple cafe-au-lait spots | 2.0% | 1/50 |
| Nail dystrophy | 2.0% | 1/50 |
| Nail dysplasia | 2.0% | 1/50 |
| Oligodontia | 2.0% | 1/50 |
| Profuse pigmented skin lesions | 2.0% | 1/50 |
| Small nail | 2.0% | 1/50 |
| Soft skin | 2.0% | 1/50 |
| Yellow nails | 2.0% | 1/50 |
| Endocrine / Immunological / Metabolic | ||
| Abnormality of the endocrine system | 13.3% | 6/45 |
| Growth hormone deficiency | 6.7% | 3/45 |
| Hypothyroidism | 4.4% | 2/45 |
| Abnormality of circulating hormone level | 2.2% | 1/45 |
| Decreased serum insulin-like growth factor 1 | 2.2% | 1/45 |
| Thyroid-stimulating hormone excess | 2.2% | 1/45 |
| Abnormality of the metabolic system | 20.8% | 10/48 |
| Abnormality of mitochondrial metabolism | 4.2% | 2/48 |
| Neonatal hypoglycemia | 4.2% | 2/48 |
| Abnormal protein O-linked glycosylation | 2.1% | 1/48 |
| Abnormality of temperature regulation | 2.1% | 1/48 |
| Abnormality of acid-base homeostasis | 2.1% | 1/48 |
| Albuminuria | 2.1% | 1/48 |
| Decreased urinary potassium | 2.1% | 1/48 |
| Decreased serum creatinine | 2.1% | 1/48 |
| Hyperkalemia | 2.1% | 1/48 |
| Hypernatremia | 2.1% | 1/48 |
| Hypercalciuria | 2.1% | 1/48 |
| Hypoglycemia | 2.1% | 1/48 |
| Hypokalemia | 2.1% | 1/48 |
| Increased serum lactate | 2.1% | 1/48 |
| Temperature instability | 2.1% | 1/48 |
| Abnormality of the immune system | 33.3% | 16/48 |
| Recurrent otitis media | 14.6% | 7/48 |
| IgA deficiency | 6.3% | 3/48 |
| Recurrent urinary tract infections | 6.3% | 3/48 |
| Abnormality of T cell number | 4.2% | 2/48 |
| Pneumonia | 4.2% | 2/48 |
| Recurrent respiratory infections | 4.2% | 2/48 |
| Recurrent upper respiratory tract infections | 4.2% | 2/48 |
| Abnormal immunoglobulin level | 2.1% | 1/48 |
| Decreased antibody level in blood | 2.1% | 1/48 |
| IgG deficiency | 2.1% | 1/48 |
| Otitis media | 2.1% | 1/48 |
| Pancreatitis | 2.1% | 1/48 |
| Recurrent bronchitis | 2.1% | 1/48 |
| Recurrent infections | 2.1% | 1/48 |
| Recurrent pneumonia | 2.1% | 1/48 |
| Recurrent viral infections | 2.1% | 1/48 |
| Sepsis | 2.1% | 1/48 |
| Specific antibody deficiency | 2.1% | 1/48 |
| Neoplasia | ||
| Neoplasia | 4.0% | 2/50 |
| Hemangioma | 2.0% | 1/50 |
| Medulloblastoma | 2.0% | 1/50 |
| Osteochondroma | 2.0% | 1/50 |