TANGO2-related disorder was first reported in 2016 by two groups. The phenotype was termed “metabolic encephalomyopathic crises, recurrent with rhabdomyolysis, cardiac arrhythmias, and neurodegeneration,” or MECRCN, for its characteristic features; other names, including “TANGO2-related metabolic encephalopathy and arrhythmias” or “TANGO2-related encephalocardiomyopathy” have also been proposed. Inheritance is autosomal recessive.
TANGO2