Patient Overview : 12

General

Frequency of all clinical findings

Percentage Cases
Gender    
Male 58.3% 7/12
Female 41.7% 5/12
General    
Birth Length abnormalities 0% 0/12
Birth Weight abnormalities 0% 0/12
Birth Head circumference abnormalities 41.7% 5/12
< P3 : Primary microcephaly 41.7% 5/12
Current Height abnormalities 0% 0/12
Current Weight abnormalities 0% 0/12
Current Head circumference abnormalities 50.0% 6/12
< P3 : Microcephaly 50.0% 6/12
Neurology    
Neurological abnormalities 100.0% 10/10
Seizure 100.0% 10/10
Infantile spasms 40.0% 4/10
Generalized hypotonia 30.0% 3/10
Bilateral tonic-clonic seizure 20.0% 2/10
Generalized tonic seizure 20.0% 2/10
Febrile seizure (within the age range of 3 months to 6 years) 10.0% 1/10
Focal impaired awareness seizure 10.0% 1/10
Generalized myoclonic seizure 10.0% 1/10
Generalized-onset seizure 10.0% 1/10
Lower limb hypertonia 10.0% 1/10
Myoclonic spasms 10.0% 1/10
obsolete Infantile axial hypotonia 10.0% 1/10
Behavioral problems 75.0% 6/8
Short attention span 37.5% 3/8
Autistic behavior 25.0% 2/8
Autism 25.0% 2/8
Anxiety 12.5% 1/8
Exaggerated startle response 12.5% 1/8
Hyperactivity 12.5% 1/8
Impulsivity 12.5% 1/8
Brain abnormality 91.7% 11/12
Ventriculomegaly 66.7% 8/12
Lissencephaly 58.3% 7/12
Abnormal basal ganglia morphology 25.0% 3/12
Abnormal corpus callosum morphology 25.0% 3/12
Cerebellar vermis hypoplasia 25.0% 3/12
Hypoplasia of the corpus callosum 25.0% 3/12
Partial agenesis of the corpus callosum 16.7% 2/12
Abnormal cerebellar vermis morphology 8.3% 1/12
Intraventricular arachnoid cyst 8.3% 1/12
obsolete Gray matter heterotopias 8.3% 1/12
Facial abnormalities    
Abnormality of the eye 37.5% 3/8
Epicanthus 12.5% 1/8
obsolete Prominent epicanthal folds 12.5% 1/8
Abnormality of the nose 25.0% 2/8
Wide nasal bridge 12.5% 1/8
Visual and hearing impairments    
Abnormal vision 45.5% 5/11
Strabismus 18.2% 2/11
Reduced eye contact 9.1% 1/11
Visual impairment 9.1% 1/11
Gastrointestinal    
Gastrointestinal abnormalities 18.2% 2/11
Feeding difficulties in infancy 9.1% 1/11
Gastroesophageal reflux 9.1% 1/11
Gastrostomy tube feeding in infancy 9.1% 1/11
Urogenital    
Abnormality of the urogenital system 25.0% 3/12
Cryptorchidism 16.7% 2/12
Glanular hypospadias 8.3% 1/12
Uric acid urolithiasis independent of gout 8.3% 1/12
Skeleton    
Skeletal abnormalities 8.3% 1/12
Clinodactyly of the 5th toe 8.3% 1/12