This website provides information on patients with mutations in the WNT10B gene, including clinical data, molecular data, management and research options.

The syndrome caused by mutations in the WNT10B gene is characterized by Split-Hand/Foot Malformation (SHFM6, MIM #225300). The spectrum includes oligodactyly, supernumerary metacarpal, metatarsal or phalangeal bones, syndactyly. The severity of the malformations is highly variable. Some patients exhibit only syndactyly or camptodactyly.

Not all individuals with a mutation in the WNT10B gene have these features.

This website was created to share and collect information about clinic, management and research projects to gather more knowledge and provide better treatment of patients with mutations in the WNT10B gene.

Brunelle Perrine, MD, University Hospital of Lille, Lille, France, perrine.brunelle@chu-lille.fr

Petit Florence, MD, PhD, University Hospital of Lille, Lille, France, florence.petit@chu-lille.fr