AD-CMD
HEAD & NECK
• Bone thickening or dense bone in skull base
• Bone thickening or dense bone in skull bones
• Wide-set eyes
• Large head circumference
• Enlarged lower jaw
• Conductive hearing loss
• Tooth malalignment
• Delayed tooth eruption
• Nasal obstruction
• Obliteration of sinuses
• Narrowing of cranial foramina including foramen magnum
SKELETAL
• Widened metaphyses of long bones
• 'Erlenmeyer flask' deformity especially visible in distal femur
• Normal spine
• Normal pelvis
CENTRAL NERVOUS SYSTEM
• Facial palsy
• Headaches due to intracranial pressure
• Loss of vision due to optic nerve impaction
• Sensorineural hearing loss
CCAL2
SKELETAL
• Calcification of cartilage in one or more joints
• Calcium pyrophosphate (CPP) dihydrate crystal deposition (knee, symphysis pubis, wrist)
• “Pseudogout” (common name for acute attacks of joint pain; similar in intensity to gout pain)
• Arthropathy
• Osteoarthritis
• Disease onset usually in the 20’s
SYSTEMIC
• Fever
• Chills
• Malaise
• Depression due to pain and disability
ANKH