Familial/Sporadic hemiplegic migraine type 2 (FHM2/SHM2) is caused by mutations in the ATP1A2 gene. FHM2/SHM2 is a subtype of migraine with aura. Migraine is a severe type of headache in which attacks are associated with intolerance to light and/or sound, nausea and/or vomiting. Sometimes these attacks are preceded by auras; a perceptual disturbance. In the case of FHM2/SHM2 as part of the aura also temporary motor weakness on one side of the body occurs. This weakness in the muscles, which is typical for FHM2/SHM2, might differ in severity from weakness in movement of only the arm or leg to an entire half of the body. People who suffer from FHM2/SHM2 might have additional problems such as epilepsy, permanent mental retardation, confusion and coma.
ATP1A2