Although a specific protocol is not currently available, each of the clinical aspects of the complex PRMT7-syndrome needs to be addressed during the follow-up of affected individuals by expert clinicians. In particular, seizures need and endocrinological abnormalities require appropriate management through medical therapy and lifestyle changes. Genitourinary abnormalities may sometimes require surgical treatment. Skeletal malformations can be managed through orthotic devices. Periodic surveillance is needed for endocrinological manifestations through metabolic and hormonal workup on a case-by-case basis.