Neurologic
• Neurodevelopmental disorder
• Brain malformations
Growth
• Short stature
• Growth retardation
Head & Neck
• Microcephaly
• Bitemporal narrowing
• Long philtrum
• Coloboma
• Short nose
• Broad nasal root
• Thin upper lip
• Short neck
Cardiovascular
• Septal defects
Abdomen
• Poor feeding
• Failure to gain weight
• Renal hypoplasia, agenesis
• Renal cysts
• Renal fusion
Skeletal
• Vertebral abnormalities, hemivertebrae, fused vertebrae
• Scoliosis
• Hip dislocation, elbow subluxation
• Short fifth fingers, clinodactyly, malpositioned thumbs
PUF60