Management

Currently, infantile spasms of SPTAN1 encephalopathy were highly refractory to treatment, and no specific treatment for epileptic encephalopathy was established. The following treatments had partial or temporally effectiveness on spasms in single patients: vigabatrin, adrenocorticotropic hormone, a combination of vigabatrin and adrenocorticotropic hormone, valproic acid, topiramate, clobazam, pyridoxal 5’-phosphate, levetiracetam and ketogenic diet. One case in which a ketogenic diet was effective for focal epilepsy has been reported.