Molecular Characteristics for Families

ZMYND11 (encoding zinc-finger MYND domain 11) is a tumor suppressor gene whose corresponding protein recognizes chromatin trimethylated at lysine 36 of histone H3.3 (H3.3K36me3) and regulates elongation by RNA polymerase II. It is associated with highly expressed genes and might be an important transcriptional corepressor early in development.