Mutations within the DNMT3A gene cause an overgrowth intellectual disability (OGID) syndrome called the Tatton-Brown-Rahman syndrome (TBRS, OMIM 615879). TBRS is a rare, autosomal dominant disorder characterised by overgrowth (increased height, weight and/or head circumference), an intellectual learning disability and children/adults often have a recognisable facial appearance.
DNMT3A