Some individuals with a NAA10-related disorder come from families that have a family history of intellectual disability. These families are often referred to genetic services, as the disorder has an X-linked pattern of inheritance. Other individuals have no such family history and the genetic change starts for the first time with them.
Males inherit an X chromosome from their mother and a Y chromosome from their father. Males who inherit an X chromosome with a NAA10 gene change will have a NAA10 related disorder. Females have two X chromosomes; one from their mother and one from their father and each X chromosome has a NAA10 gene. Females who have a gene change in one of their NAA10 genes are called carriers.
The original family with a mutation in NAA10 lived in Ogden, Utah, so the syndrome was initially called Ogden syndrome. Now it is usually referred to as NAA10-related disorder.