TDP2 is a DNA repair gene encoding the protein tyrosyl DNA phosphodiesterase 2 (TDP2). TDP2 protein promotes the repair of DNA double-strand breaks created by the erroneous/abortive activity of topoisomerase II (TOP2). TDP2 hydrolyses the covalent bond linking TOP2 to the 5’-terminus of such DSBs, freeing the DNA ends for DNA ligation.
TDP2