Case reports and clinical studies:
Chen CP et al. A 5.6-Mb deletion in 15q14 in a boy with speech and languagedisorder, cleft palate, epilepsy, a ventricular septal defect, mental retardation and developmental delay. European Journal of Medical Genetics 2008, 51(4), 368–372.

Crowley MA et al. Further evidence for the possible role of MEIS2 in the development of cleft palate and cardiac septum. American Journal of Medical Genetics. Part A 2010, 152A(5), 1326–1327.

Douglas G et al. De novo missense variants in MEIS2 recapitulate the microdeletion phenotype of cardiac and palate abnormalities, developmental delay, intellectual disability and dysmorphic features. American Journal of Medical Genetics. Part A 2018, 176(9), 1845–1851.

Erdogan F et al. Characterization of a 5.3 Mb deletion in 15q14 by comparative genomic hybridization using a whole genome “tiling path” BAC array in a girl with heart defect, cleft palate, and developmental delay. American Journal of Medical Genetics. Part A 2007, 143A(2),172–178.

Fujita A et al. De novo MEIS2 mutation causes syndromic developmental delay with persistent gastro-esophageal reflux. Journal of Human Genetics 2016, 61(9), 835–838.

Gangfuß A et al. Intellectual disability associated with craniofacial dysmorphism, cleft palate, and congenital heart defect due to a de novo MEIS2 mutation: A clinical longitudinal study. Am J Med Genet Part A. 2021; 185A:1216–1221.

Giliberti A et al. MEIS2 gene is responsible for intellectual disability,cardiac defects and a distinct facial phenotype. European Journal of Medical Genetics 2020, 63(1), 103627.

Johansson S et al. Haploinsufficiency of MEIS2 is associated with orofacial clefting and learning disability. American Journal of Medical Genetics. Part A 2014, 164A(7), 1622–1626.

Louw JJ et al. MEIS2 involvement in cardiac development, cleft palate, and intellectual disability. American Journal of Medical Genetics. Part A 2015, 167A(5), 1142–1146.

Smith JE et al. Chromosomal mapping to 15q14 and expression analysis of the human MEIS2 homeobox gene. Mamm Genome 1997, Dec;8(12)951-952

Verheije R et al. Heterozygous loss-of-function variants of MEIS2 cause a triad of palatal defects, congenital heart defects, and intellectual disability. European Journal of Human Genetics 2019, 27(2), 278–290.

Preclinical models and studies (selection):

Face, jar, palate:
Machon O et al. Meis2 is essential for cranial and cardiac neural crest development. BMC Dev Biol. 2015, 15:40. doi: 10.1186/s12861-015-0093-6. PMID: 26545946

Wang L et al. The transcriptional regulator MEIS2 sets up the ground state for palatal osteogenesis in mice. J Biol Chem. 2020, 295(16):5449-5460. doi: 10.1074/jbc.RA120.012684. PMID: 32169905

Agoston Z et al. Meis2 is a Pax6 co-factor in neurogenesis and dopaminergic periglomerular fate specification in the adult olfactory bulb. Development. 2014, 141(1):28-38. doi: 10.1242/dev.097295. PMID: 24284204

Frazer S et al. Transcriptomic and anatomic parcellation of 5-HT3AR expressing cortical interneuron subtypes revealed by single-cell RNA sequencing. Nature Commun. 2017, 8:14219. doi: 10.1038/ncomms14219. PMID: 28134272

Jakovcevski M et al. Neuronal Kmt2a/Mll1 histone methyltransferase is essential for prefrontal synaptic plasticity and working memory. J Neurosci. 2015, 35(13):5097-108. doi: 10.1523/JNEUROSCI.3004-14.2015. PMID: 25834037

Kolb J et al. Arginine Methylation Regulates MEIS2 Nuclear Localization to Promote Neuronal Differentiation of Adult SVZ Progenitors. Stem Cell Reports. 2018, 10(4):1184-1192. doi: 10.1016/j.stemcr.2018.03.010. PMID: 29641989

Vitobello A et al. Hox and Pbx factors control retinoic acid synthesis during hindbrain segmentation. Dev Cell. 2011, 20(4):469-82. doi: 10.1016/j.devcel.2011.03.011. PMID: 21497760

Paige SL et al. A temporal chromatin signature in human embryonic stem cells identifies regulators of cardiac development. Cell. 2012, 151(1):221-32. doi: 10.1016/j.cell.2012.08.027. PMID: 22981225

Capdevila J et al. Control of vertebrate limb outgrowth by the proximal factor Meis2 and distal antagonism of BMPs by Gremlin. Mol Cell. 1999, 4(5):839-49. doi: 10.1016/s1097-2765(00)80393-7. PMID: 10619030

Delgado I et al. Control of mouse limb initiation and antero-posterior patterning by Meis transcription factors. Nat Commun. 2021, 12(1):3086. doi: 10.1038/s41467-021-23373-9. PMID: 34035267

Fischer ES et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014, 512(7512):49-53. doi: 10.1038/nature13527. Epub 2014 Jul 16. PMID: 25043012

Mercader N et al. Opposing RA and FGF signals control proximodistal vertebrate limb development through regulation of Meis genes. Development. 2000, 127(18):3961-70. PMID: 10952894

Yakushiji-Kaminatsui N et al. RING1 proteins contribute to early proximal-distal specification of the forelimb bud by restricting Meis2 expression. Development. 2016, 143(2):276-85. doi: 10.1242/dev.127506. PMID: 26674308

Conte I et al. miR-204 is required for lens and retinal development via Meis2 targeting. Proc Natl Acad Sci U S A. 2010 Aug 31;107(35):15491-6. doi: 10.1073/pnas.0914785107.

Heine P et al. Evidence for an evolutionary conserved role of homothorax/Meis1/2 during vertebrate retina development. Development. 2008 Mar;135(5):805-11. doi: 10.1242/dev.012088. PMID: 18216174

Zhang X et al. Meis homeoproteins directly regulate Pax6 during vertebrate lens morphogenesis. Genes Dev. 2002, 16(16):2097-107. doi: 10.1101/gad.1007602. PMID: 12183364

Durán Alonso MB et al. Meis2 Is Required for Inner Ear Formation and Proper Morphogenesis of the Cochlea. Front Cell Dev Biol. 2021, 9:679325. doi: 10.3389/fcell.2021.679325. PMID: 34124068

Genomic, mechanistic:
Amin S et al. Hoxa2 selectively enhances Meis binding to change a branchial arch ground state. Dev Cell, 2015, 32(3):265-77. doi: 10.1016/j.devcel.2014. PMID: 25640223

Hau SC et al. MEIS homeodomain proteins facilitate PARP1/ARTD1-mediated eviction of histone H1. J Cell Biol. 2017, 216(9):2715-2729. doi: 10.1083/jcb.201701154. PMID: 28739678

Penkov et al. Analysis of the DNA-binding profile and function of TALE homeoproteins reveals their specialization and specific interactions with Hox genes/proteins. Cell Rep. 2013, 3(4):1321-33. doi: 10.1016/j.celrep.2013.03.029. PMID: 23602564