Preclinical research on MEIS2 uses animal models or cell culture systems to understand the phenotypes that are caused by MEIS2 genetic alterations. Active research involves the generation of transgenic mouse models that carry different genetic mutations of Meis2 to study their conse-quence during embryogenesis (e.g. Delgado et al., 2021; Machon et al., 2015), the analysis of genes and pathways that control the expression or availability of MEIS2 by, for example, by analyzing the epigenome or proteome of cells (e.g. Conte et al., 2010; Fischer et al., 2014; Kolb et al., 2018; Mercader et al., 2000; Paige et al., 2012), the identification of genes that are themselves under control of MEIS2 by high-thoughput or single-cell RNA sequencing (e.g. Frazer et al., 2017; Zhang et al., 2002), and the mechanisms by which MEIS2 impacts the activity of these genes using, for instance, chromatin-immunoprecipitation (e.g. Amin et al., 2015; Hau et al., 2017; Penkov et al., 2013).
MEIS2